Citrullination, a post-translational modification of proteins catalysed by peptidyl-arginine-deiminase (PAD) enzymes, plays a critical role in the formation ...

Study reveals how an RNA enzyme drives the postnatal switch from glucose to fatty acids in heart cells, highlighting ketogenesis as essential for metabolism. Study: The tRNA methyltransferase Mettl1 ...

The amino acid side chains of proteins undergo various post-translational modifications (PTMs) which significantly impact protein function and mediate complex cellular events. Measuring the dynamics, ...

At the University of Oxford, scientists have developed a nanopore technology that can identify three different post-translational modifications (PTMs) in individual proteins, even deep within long ...

Inside every human cell, proteins are constantly being tagged with small chemical modifications after they're produced. Known ...

Biochemists from the National University of Singapore (NUS) have discovered a new subclass of trifunctional enzymes in gram-positive bacteria, which play a critical role in the biosynthesis of an ...

Protein changes matter: Scripps Research showed that post-translational modifications can make proteins more or less responsive to drug-like molecules, affecting treatment success. Genetics meets ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Researchers at Università Cattolica and Fondazione Policlinico Universitario A. Gemelli IRCCS demonstrated that cognitive decline and brain damage typical of Alzheimer’s disease can be counteracted in ...